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5 On-Premise equipment to ensure amazing conversation, productiveness, and Collaboration in protection conversation, productivity, and Collaboration are the foundations of any defense force or defense group. devoid of a sturdy effectivity, fit talk between crew members, and powerful collaboration between departments, protection teams would founder amid a disorganized babble. Planning, reporting, monitoring, and managing: these basic job necessities of mission-conscious military teams cannot be fulfilled without a joined-up strategy. in any case, productiveness of protection groups, in each element, is reliant upon sound collaboration communication. the place as soon as roles had been assigned via a mobilephone call or order letters, in these days’s digital age there are distinctive characteristic-wealthy apps or systems that increase the tangible contact of ear to handset or palm to palm. For an on-mission protection crew, having a pretty good collaboration and guaranteeing on-aspect team communication continues to be vital as ever. but with the introduction of creative software, these two critical projects have develop into easy too. team communique apps or platforms ability there is not any excuse for mission-failure or shortcomings because of a message or file going awry. knowing On-Premise utility installation & Why they’re important First thing’s first – cloud computing certainly presents newfound flexibility for corporations. It has benefits such as agility, scalability, time and funds saving. nevertheless, on-premise utility installations – that are carried out or put in on a company’s own servers – continues to be no longer the most everyday choice. however, there’s no denying the fact that on-premise installations are respectable, comfortable, and that they present greater manage to the admin. in brief, they allow admin or the enterprise to have a stage of control that the cloud commonly can’t. On-premise utility installation requires the corporation or company to purchase the license or a duplicate of the app to make use of it. since the comprehensive software is bought, it resides inside an commercial enterprise’s premises. therefore, it presents a more suitable protection as compared to the cloud computing infrastructure. That’s the cause many security aware organisations like govt corporations, protection or militia teams decide on on-premise software over cloud computing infrastructure. in this blog post, we are going to talk about five best on-premise crew verbal exchange tools that, if used accurately, will enrich verbal exchange, increase efficiency, and increase collaboration between defense groups. Let’s talk. build above all for defense collaboration features, Troop Messenger is one of the most typical decisions for safety-mindful defense force firms. it is a far flung crew collaboration software pitched at each the small and medium-sized corporations. precise-time messaging, screen sharing, dropbox and Google pressure integration are all a part of the kit, and orange individuals (exterior guest clients equivalent to freelancers, carriers, suppliers) can additionally get entry to extra centralize dialog. Why is Troop Messenger gold standard for Defence Communications? as far as the functionalities and features are concerned, Troop Messenger is sure to exceed your expectations. sure, you get all of the commonplace ones – audio and video conferencing, unlimited deepest chats, unlimited group chats, handy file sharing, recall messages, and skim receipts– but you’ll have a defense organization, you’ll exceptionally benefit from: possible On-Premise deployment Multi-layered security for all records Fingerprint and Passcode authentication access Surveillance function to intently video display conversation. live tracking Multi-layered admin privileges records encryption whereas at transit and relaxation inner most Chat Burnout Window for private conversations GDPR Compliance Mitigated risk of data theft Encrypted and secure army safe file switch as a result of Troop Messenger can with no trouble be built-in with the likes of Google drive, LDAP, Dropbox, you get the choice to view and share information with out leaving the chat window. The best thing about Troop Messenger is the distinctive implementation options (deepest Cloud, Public Cloud, On-Premise) and feasible deployment. that you may self-host the app at your on-premise server or on the inner most/public cloud. This crew conversation app additionally has a ‘cover and are seeking for’ function that enables admins to enable/disable aspects they consider comfortable/insecure about at a selected moment. As a quickest starting to be workplace chat app, Troop Messenger is basically one to agree with if boosting productivity, collaboration, and communication is your purpose – one of the most low-cost chat apps for the reason that their plans birth from $1 per user per thirty days. DSA (protection Collaboration features) An open-source-based mostly means, referred to as defense Collaboration services (DCS), rolled out through protection assistance systems agency (DISA) is among the greatest well-known conversation and collaboration equipment for defense groups – and for respectable motives. “It’s very relaxed, the use of the latest trade standards and hosted inside cozy DISA facts facilities,” says Karl Kurz, DISA application manager. “We truly live on milCloud, the DoD hosting atmosphere it is cozy and extremely bendy. any person who has approved community entry is approved to create an account on DCS and then dangle conferences the usage of this service.” well-nigh a hub for defense messaging, DCS helps groups store time, chiefly which they’d otherwise spend trawling during the limitless emails. It permits a comfy room-based mostly chat with distinctive team individuals and additionally person-to-person immediate text messaging. Chat windows, bookmarked rooms, create rooms, join rooms, roster, multi-user room, and presence indicator: all chat points can reside under DCS’s radically productive umbrella. Why is DCS surest for protection conversation? With DCS you get an awful lot greater than a at ease messaging platform. Take a glance: net Conferencing: all through a gathering which you could operate laptop sharing, file sharing, text chat, use white board, ballot/vote. Recording meetings: With DCS, meeting individuals can additionally record the conferences and playback periods as required. all the DCS conferences are retained for one hundred eighty Days however recorded classes can handiest be downloaded through admins for distribution to certain audiences. doc Sharing: Powerpoint, Excel, PDF formats, and Microsoft note Chat: Persistent Chat rooms, presence indicator, and one-to-one chats so far as security is involved, DCS’s credentials are surprising with integration with DoD public key infrastructure – a framework that additional integrates public key cryptography, digital certificates, and certification authorities right into a DoD-broad CAC-based community protection structure. And did I mention DCS uses milcloud for facts storage – permitting all clients to take skills of milCloud’s peculiarly at ease cloud storage environment, and further scale DCS as required. defense enterprise workplace answer (DEOS) protection commercial enterprise office solution, abbreviated as DEOS, is an commercial enterprise commercial cloud ambiance that supports the DoD strategy to purchase and enforce business functions and capabilities for joint use across the branch, standardize cloud adoption, and enable go-department collaboration. clients have raved about its capability to reduce the complex assistance change, interfaces, and interconnection through helping a balanced evolution of collaboration services with business upgrades. Why is DEOS surest for protection communication? a few of its USP’s include business-stage service (featuring local survivability and geographic redundancy), world access (CONUS and OCONUS connectivity and IL5 and 6 entry), and tier based pricing (tiered pricing lowers the barrier for adoption, so that you pay for the services you use). but there’s extra to avail via DEOS. Take a glance: productivity Suite: note Processor, Spreadsheet, mission Scheduling, monitoring, Presentation, Drafting & Diagramming, and Database administration content management: File Sharing & Storage, Index, Filter & Search, web Portal, and Workflows. Collaboration: web Conferencing, Audio & Video Calling, computing device Sharing, Presence indicator, IM, Persistent neighborhood Chat Voice: business Voice, Residential voice, Voicemail, business voice entry, and Unified Messaging called digital office application, Exoplatform is likely one of the quickest transforming into defense communique software. Exoplatform is regular chiefly for its relaxed chat functionality, but there’s a whole lot else besides. communicate, Collaborate, Empower, and Reward – these are the four simple add-ons of Exoplatform. below the communication tab, you get prosperous aspects like information advent for all team contributors, page creation, exterior media sharing, and greater. Pulling your team together is just a depend of sharing a customized hyperlink and scheduling essential meetings couldn’t be more straightforward. if you’d like to review a gathering at a later date, whether to refresh your memory of a speakme aspect or to clarify some numbers, simply be sure to list it in the first instance. you can additionally share screens, annotate PowerPoint to collaborate in real-time, take capabilities of facets like editable whiteboards and polls, and count on 24/7 mobilephone assist as needed. Why is ExoPlatform most desirable for defense communique? With Exoplatform, you have got at your disposal, a big range of collaboration features: via deepest cozy areas, protection teams can collaborate on advert hoc initiatives There’s no excuse for missing cut-off dates or meeting venture requirements with a state-of-the-paintings array of collaboration tools such as areas, documents, projects, calendars, chats, and endeavor streams. increase communication with private companions or interior groups via one-on-one conversations or neighborhood chats. so far as safety is concerned, the app ensures complete compliance with safety and all privacy necessities. As an admin, which you could take manage of on-premise implementation in the course of the confirmed open-source requirements of Exoplatform. All in all, there’s no excuse for assistance trade to be anything else other than tremendous secure. Given the handy access to quite a number useful aspects, now not to point out the protection-stage protection, it’s a safe alternative for military and executive businesses. It’s not a secret that protection groups or military businesses manage a huge volume of approvals and initiatives on a regular groundwork. organizations like these deserve to leverage type aside technologies and assignment administration methods to enhance both collaboration and team productiveness. Accenture Federal services’ task administration tool is without doubt one of the familiar tools used by means of protection groups to cut back missed closing dates and improve team of workers efficiency. With this device, protection teams get to avail seamless collaboration and communique and therefore convey greater meaningful effects. With seamless enterprise-huge collaboration, automation, and relaxed counsel change between the crew contributors, assignment management device not best hurries up strong mission start but additionally simplifies assignment management. Why is Accenture TMT a great app for protection communique? Fewer neglected closing dates – that’s one of the crucial amazing events of the use of TMT and apps alike. When group individuals are at all times in touch and have entry to all firm choices, and adminds have the ability of assessing personnel effectivity and organizational efficiency – teams work more efficiently, and omit lesser closing dates. however there’s greater to Accenture’s TMT as a defense conversation app: Assign initiatives to people or teams Create stages of assignments or sub-assignments as obligatory Centralized file storage One-button, on-web page approval enable all of the staff to assessment who’s doing what permit sending/receiving immediate updates in accordance with the circumstance reveal the precise-time response and standing visibility throughout the crew entry to background of the entire corporation choices and americans concerned Metric primarily based capacity for assessing body of workers efficiency Conclusion expectantly this rundown of defense verbal exchange equipment will make you and your crew come to a decision about the most beneficial on-premise chat app. Whichever one you select, these rapid messaging and remote collaboration apps will speed up your group’s effectivity, set the stage for true-time dialog, help to deliver your crew together, and give your crew individuals the centralized tools they should be extra productive. we are able to’t make a decision for you, but if all of the aspects and functionalities of the above 5 apps are in comparison, Troop Messenger truly has more to offer in terms of communication, collaboration, and effectivity. What Makes Troop Messenger a better choice? Like all of the other 4 apps, Troop Messenger offers essentials similar to one-on-one messaging, audio & video calling, laptop sharing, group chat, and comfy file sharing. the place Troop Messenger definitely shines is: Burnout Window – A confidential chat window the place exchanged messages automatically expire after a stipulated time duration. precise-Time place Sharing: With Troop Messenger, admins can live music their Troops together with the conversation updates to bear in mind the interesting challenges they face. Play disguise and are seeking: permit/Disable the aspects you consider comfortable/insecure about at that second. Surveillance feature: As an admin, you can closely display screen your groups communique and advice trade information ownership: personal all of the message-exchanges and manage your facts house either with collaborative or single-element ownership. remember, a protection group chat app that prioritizes statistics security and admin manage is extra more likely to keep away from the disruption all through mission-critical cases brought about with the aid of information theft or protection breaches. writer: Mohsin Ansari Md Mohsin Ansari is a marketing supervisor at Troop Messenger – a crew communique utility that incorporates the entire requisite elements. it is a possible Slack option it truly is spreading its wings throughout all industries by bringing the entire internal communication at one area. Mohsin is liable for examining… View full profile › CRISPR value Chains aid New Therapeutic strategies Swift growth in gene editing technology is bringing hope to individuals who undergo from incurable genetic diseases. Staying on route, youngsters, will also be problematic. it’s all too effortless to run afoul of intellectual property (IP) rights, which have restrained some groups’ freedom to operate. To steer clear of such risks, organizations are developing novel CRISPR compositions that may deliver better specificity, effectivity, and fidelity. besides functioning as a research tool, gene modifying is producing cures that are urgent ahead to the health facility. Many expertise remedies are already in the pipeline to deal with a number of diseases, and many extra healing procedures are coming into the pipeline as part suppliers expand their product choices. In vivo and ex vivo approaches “it’s an exhilarating time for medicine as we progress towards constructing transformative, durable drugs for americans residing with critical illnesses of unmet need,” says Kate Zhang, PhD, vice chairman, biological building, Editas drugs. The company’s lead pipeline candidate is EDIT-one zero one, which is at the moment in medical building for the treatment of Leber congenital amaurosis 10 (LCA10), a infrequent inherited retinal degenerative disorder that explanations blindness or severe visual impairment at start or all over the first months of life. in response to Zhang, Editas plans to file an investigational new drug (IND) utility by means of the end of the 12 months for an extra remedy, EDIT-301, which has shown promise in fresh preclinical experiences. With EDIT-301, cells are collected from a patient, genetically edited, after which finally again to the affected person to treat sickle-telephone sickness. The cells are CD34+ hematopoietic stem cells, and they’re edited on the HBG1/2 promoter in the β-globin locus using CRISPR-Cas12a (also known as Cpf1) to result in fetal hemoglobin (HbF) in naturally happening mutations. IND-enabling reports even have been initiated for EDIT-201, an allogeneic natural killer (NK)–cell medicine for the medicine of strong tumor cancers. entry to both Cas9 and Cas12a permits Editas to use whichever nuclease will execute the most fulfilling edit, explains Zhang. CRISPR-Cas12a is structurally distinctive, and its know-how has independent IP. The advantage merits include an elevated variety of editable sites as a result of diverse protospacer adjoining motifs, and multiplied efficiency and accuracy for some kinds of gene repair due to staggered DNA cuts. This natural system is more straightforward  to manufacture and bring, requiring handiest a short, single CRISPR e-book RNA (gRNA) and no trans-activating CRISPR RNA (tracrRNA). throughout the development of EDIT-301, Editas in comparison SpCas9 and Cas12a. The latter verified a advanced modifying profile on the HBG distal CCAAT field region for persistent and excessive HbF expression. The preclinical in vivo facts proven doubtlessly therapeutically advisable and amazing excessive stages of HbF expression with long-term sturdiness and pancellular distribution. capable of highly effective knockout and transgene knockin across a variety of phone types including precipitated pluripotent stem cells (iPSCs), Cas12a no longer most effective has a positive editing profile, it will probably significantly raise the possibilities of producing clones with constructs that may power potent allogeneic cellphone remedies. Allele-selected enhancing Emendo Biotherapeutics discovers and develops novel optimized nuclease-gRNA compositions that enable allele-particular editing. The compositions aim to deal with autosomal dominant disorders, which symbolize most untreatable genetic ailments. The autosomal dominant disease known as extreme congenital neutropenia (SCN) is of certain activity to the business. In SCN, mutations in the ELANE gene, which encodes neutrophil elastase, stay away from the maturation of neutrophils and compromise the immune device’s capacity to combat infections. more than 200 SCN-linked mutations in ELANE were characterized. focused on each and every one to knockout the mutated allele is impractical. to supply a drug unique for a selected indication, Emendo Biotherapeutics follows a three-stage system: discovery—analyze mechanism of action, genetic variations, and the like, and design a correction approach; lead optimization—take a composition through protein engineering, guide design, and platform selection; development—validate the modifying strategy on patient-derived cells and set up collaborations and partnerships. “as an alternative, we recognized single nucleotide polymorphisms (SNPs) through analyses of databases of healthy cohorts to enable better coverage of the affected person population with a number of nuclease-gRNA mixtures,” relates Rafi Emmanuel, PhD, vp of R&D at Emendo. “We recognized three SNPs for ELANE that cover about eighty% of the inhabitants. In collaboration with the school of Washington in Seattle, we used sufferers’ sequence statistics to reveal the equal occurrence of the SNPs in the patients’ cohort. We rely on SNPs to knockout most effective the mutated allele, a really difficult discrimination level.” because of the barriers of spCas9, Emendo is now specializing in discovering new nucleases, termed OMNI Nucleases. the use of a number of proprietary libraries, Emendo performs an initial SNP-based option in bacteria to obtain variants that discriminate between wild-class and mutated alleles. “We comply with a number of cycles of high-quality and terrible choice,” Emmanuel details. “The SNPs may also be in either the wild category or mutated allele. for this reason, we select our variations on each alleles and validate that they are selected to both in line with the book it is getting used for the modifying. for 3 SNPs, we need six compositions.” When selected nuclease versions are sought, selectivity or exercise is commonly compromised. A variant selected in bacteria may additionally no longer be very energetic in mammalian cells; for this reason, an extra system of variant screening in mammalian equipment is carried out, which usually ends with a handful of variations. The alternative method is continually optimized. “We desire extra editions that are crucial to our wants,” Emmanual emphasizes. “[They need to be] as lively because the wild type and supply bigger constancy and specificity.” Nonviral gene editing melanoma immunotherapies that deploy chimeric antigen receptor (car) T cells are starting to attain the medical institution. as an instance, the FDA has accredited the motor vehicle T-cell cures referred to as Kymriah and Yescarta, which are being commercialized through Novartis and GileadSciences, respectively. each Kymriah and Yescarta are autologous items. despite the fact autologous automobile T cells reveal promise, producing them is challenging. significant numbers of T cells need to be remoted from late-stage sufferers, and production and satisfactory control should be complete inside three weeks. These difficulties can be avoided if “off the shelf” allogeneic automobile T cells are processed from fit donors’ T cells. The allogeneic approach also guarantees more straightforward manufacturing scale-up and lessen treatment fees. however the allogeneic strategy poses challenges of its own. The allogeneic automobile T cells could cause lifestyles-threatening graft-versus-host disease, or they can be swiftly eradicated through the host immune device. happily, as contemporary publications have confirmed, these challenges can also be overcome supplied the acceptable innovations are implemented.1–three One approach involves a mixture of CRISPR gene modifying equipment and viral vectors to accomplish multiplex genome engineering. another method is using nonviral CRISPR enhancing systems.four,5 Nonviral strategies for engineering automobile T cells will also be safer and extra in your price range than viral methods. for example, automobile aspects may also be inserted greater precisely with nonviral strategies than with viral methods, lessening the possibility of oncogenic insertion. also, nonviral strategies pose fewer immunogenicity considerations that do adeno-associated virus vectors.6 at last, DNA payload manufacturing is less costly and quicker with nonviral vectors than it’s with viral vectors. because creation doesn’t use mammalian mobile traces or animal-derived items, substances require less complex exceptional handle. A complete CRISPR product portfolio for nonviral cellphone engineering is offered by using GenScript Biotech. “For the early discovery stage,” says Lumeng Ye, PhD, a senior scientist at the company, “CRISPR gRNA screening libraries, high-purity sgRNAs, Cas9 enzymes, and single-stranded DNA automobile/T-mobile receptor knockin templates for top-efficiency gene engineering are available. “When moving to manner development, we have amazing Cas9 nuclease, sgRNA, and DNA payload materials that may also be produced at giant scale. we’re also expanding our capacity to GMP manufacturing.” Developed and optimized for decades, viral vectors will remain conventional gene modifying tools even after nonviral vectors become more effective and achieve common adoption. What distinguishes nonviral vectors, Ye suggests, is manufacturing simplicity and ease of use. These attributes will assist nonviral vectors mature greater immediately than viral vectors. medical-grade RNPs In 2017, Aldevron became the first enterprise to launch GMP SpCas9 protein as a catalog product. The move reassured researchers who doubted whether they might supply clinical-grade CRISPR proteins. “The field has come a protracted method in three years,” says Max Sellman, product supervisor, gene modifying, Aldevron. “Now greater than 60 corporations use gene editing options to deal with a broad diversity of ailments.” The vital first gene editing step is developing the energetic CRISPR machinery. presently, most medical-stage mobile cures contain “element of use” complexing of the Cas9 and sgRNA to form active ribonucleoprotein (RNP), which is immediately utilized to cells. This procedure can be subjected to little or no pleasant trying out. So, the degree to which the system succeeds in any given run, or demonstrates consistency from run to run, could be doubtful. Now businesses are concerned with scale-up and technique consistency, relates Sellman. They want assurances that their gene editing processes are completely controlled without a batch adjustments between RNP composition and performance. a brand new platform below development will carry personalized Cas9 RNP for clinical use. Aldevron will advanced together GMP Cas9 plus a customized sgRNA and convey competent-to-use RNP advanced with a full certificates of analysis. A constant RNP source with established requirements simplifies the manufacturing process for telephone remedies whereas offering tighter pleasant manage in a key early step. The RNP manufacturing process is designed round off-the-shelf CRISPR proteins, mainly wild-class SpCas9 and engineered SpyFi™ Cas9 nucleases, both purchasable at GMP exceptional. for the reason that the certain sequence of the sgRNA will range, Aldevron is working with key gRNA suppliers to be sure that valued clientele can opt for their preferred brand in compliance with Aldevron’s quality equipment requirements. “we’re a customized company at heart, so we are able to adjust our usual technique to fulfill individual requirements,” informs Sellman. “focused for medical use, our new RNP manufacturing platform is choicest served by cGMP or GMP-source nice grades of provider; analysis-grade first-rate may well be relevant for some applications. The manner is very scalable from milligram to multigram amounts.” all of it begins on the benchtop In 1998, whereas working at the Carnegie institution in Washington, DC, Craig Mello, PhD, of the institution of Massachusetts medical school (UMMS), and Andrew fireplace, PhD, of Stanford tuition, found RNA interference (RNAi). Their work earned them the 2006 Nobel Prize in Physiology or drugs. The gene remedy programs on the university of Massachusetts medical school (UMMS) have advanced drastically through the years in view that their humble starting in 2007. during this diagram, which became supplied via the UMMS office of expertise administration, the desirable half shows the simple IP buildout period (together with new agencies and license endeavor), and the backside half shows analysis and medical milestones. although the surest in scientific recognition took just eight years, regulatory popularity of RNAi took an additional 12 years, notes Satinder Rawat, PhD, senior licensing officer, UMMS. As part of the core crew on the UMMS workplace of technology management, Rawat is aware the crucial points of transferring educational intellectual property. “We both use application tools or create our personal benchmarks whereas making use of our community right through our assessments,” he details. “agencies and traders are cautious about very early stage and novel technologies. Our approach is to create a expertise bucket with a spotlight on novelty and great. a few of our courses have progressed to scientific trials, a great deal further than different universities.” Rawat cross-pollinates new ideas via growing intra- and interuniversity collaborations. “facets of highbrow property exist in each contract,” he explains. “Relationship building is vital to licensing and collaborations in addition to generating provider contracts for the cores.” In 2008, he took on the task of building a new gene remedy expertise portfolio. besides the fact that children the portfolio aroused skepticism initially, it has because figured within the launch of a few startups. as an instance, gene birth know-how developed by Robert Kotin, PhD, of UMMS is being commercialized by means of technology Bio. The enterprise, which Kotin co-based, packs genetic payloads into lipid nanoparticles that are preferentially taken up by the liver. “technology takes loads of different paths,” advises Rawat. “nonetheless it at last gets to the appropriate people and partners.” a new approach the branch adopted has become a relentless mannequin for novel applied sciences; groups make investments within the analysis ahead of licensing, inserting dollars into the discovery laboratory. now not simplest is that this mannequin much less expensive than starting a brand new lab, it gives the company access to deep scientific expertise. “You want investment before whatever turns into a product,” proclaims Rawat. “Our scientists can develop into a digital analysis group whereas keeping IP possession that we are able to license sooner or later. We elevate the possibility unless the technology is confirmed.” References1. Depil S, Duchateau P, Grupp SA, et al. ‘Off-the-shelf’ allogeneic motor vehicle T cells: building and challenges. Nat. Rev. Drug Discov. 2020; 19(three): 185–199. DOI: 10.1038/s41573-019-0051-2.2. Quach DH, Becerra-Dominguez L, Rouce RH, Rooney CM. a methodology to offer protection to off-the-shelf mobile therapy products the use of virus-certain T-cells engineered to dispose of alloreactive T-cells. J. Transl. Med. 2019; 17(1): 240. DOI: 10.1186/s12967-019-1988-y.three. Mo F, Watanabe N, McKenna MK, et al. Engineered off-the-shelf therapeutic T cells face up to host immune rejection. Nat. Biotechnol. 2020; Jul 13. DOI: 10.1038/s41587-020-0601-5.four. Stadtmauer EA, Fraietta JA, Davis MM, et al. CRISPR-engineered T cells in patients with refractory melanoma. Science 2020; 367(6481): eaba7365. DOI: 10.1126/science.aba7365.5. Roth TL, Puig-Saus C, Yu R. Reprogramming human T mobilephone feature and specificity with non-viral genome targeting. Nature 2018; 559(7714): 405–409. DOI: 10.1038/s41586-018-0326-5.6. Verdera HC, Kuranda k, Mingozzi F. AAV Vector Immunogenicity in people: a protracted adventure to successful Gene switch. Mol. Ther. 2020; 28(three): 723–746. DOI: 10.1016/j.ymthe.2019.12.010..




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